Chloramphenicol

1. Treat: Bacterial conjuctivitis + otitis externae
2. M.O.A : Broad spectrum. Bacteriostatic (low doses)
Geeks: Blocks the ribosomes, so no proteins are made and bacetria cant survive.
3. Side-effects
Topically: sting/burn/itch
Systemically: anaemia/bone marrow suppression/grey baby syndrome
4. AVOID
History of bone marrow issues | Pregnant | Breastfeeding| Under 2 yrs
5. Forms: Eye drop (0.5%) /ointment (1%) | Ear drop 5-10%
6. Dose
one drop every 2hrs for first two days, then every four hours for last three days.
If infection is less severe , GP might say one drop 3-4 times a day
Ointments, longer lasting so just three to four times a day.
Drops can used in day whilst ointment at night.
7. Storage: drops (kept in fridge)
8. Key Advice
Following application to eyes ensure vision is clear before doing any tasks
Avoid contact lenses
Wash hands before use
Escalate to GP if after 2 days symptoms get worse.
